Tech Stack

Description

You will independently execute and optimize complex single-cell and spatial genomics workflows to support development of robust Laboratory Developed Tests. You will design analytical validation experiments, mentor junior staff, and collaborate cross-functionally to advance assay development milestones.

Requirements

• Ph.D. in Molecular Biology, Genetics, Biochemistry, or related field (or M.S. with equivalent industry experience)
• 3+ years (Ph.D.) or 5+ years (M.S.) hands-on industry experience in molecular diagnostics or genomics assay development
• Extensive direct hands-on experience with 10x Genomics single-cell and/or spatial technologies including troubleshooting and optimization
• Demonstrated ability to independently adapt and refine published molecular biology protocols
• Strong background in NGS workflows including nucleic acid extraction, PCR/qPCR, and library preparation
• Experience working with complex or low-input clinical samples (e.g., FFPE tissue, primary tumor material)
• Experience with cell culture methods

Responsibilities

• Independently execute complex single-cell and spatial genomics workflows including sample processing, library preparation, and sequencing
• Serve as hands-on technical expert for 10x Genomics platforms (Chromium, Xenium) with direct responsibility for assay performance
• Systematically troubleshoot and optimize assay workflows to improve robustness, sensitivity, and reproducibility
• Adapt, refine, and extend published protocols to meet clinical, regulatory, and scalability requirements
• Design and execute feasibility studies evaluating new reagents, chemistries, instrumentation, and workflow improvements
• Process diverse and challenging clinical sample types in support of clinical research and validation studies
• Design and execute experiments supporting analytical validation including accuracy, precision, limit of detection, and reproducibility
• Generate, review, and maintain high-quality laboratory documentation including SOPs, validation protocols, and batch records in accordance with Good Documentation Practices
• Analyze assay performance metrics and quality control data to drive data-based technical decisions
• Clearly present experimental data and scientific conclusions in team meetings and written reports
• Provide day-to-day technical guidance and mentorship to junior staff
• Review experimental plans, data, and lab records generated by others to ensure scientific rigor and documentation quality
• Support onboarding and training of new team members on 10x platforms, assay workflows, and laboratory best practices
• Lead by example through hands-on bench work while contributing to team planning and prioritization
• Collaborate with R&D Scientists, Automation Engineers, Bioinformatics, and CLIA Operations teams to advance assay development milestones
• Lead transfer of optimized assay workflows into the CLIA laboratory
• Work with lab operations to maintain a high-quality laboratory environment including inventory management, equipment calibration, and safety compliance