🛠 Tech Stack

💼 About This Role

You'll join the Nonclinical Development and Clinical Pharmacology team to develop PBPK-QSP models for small molecule oncology programs targeting RAS-addicted cancers. Your core impact is translating mechanistic understanding into clinical dose and efficacy projections. This role offers exposure to next-generation inhibitor design and combination therapy assessment.

🎯 What You'll Do

• Develop and refine QSP, PBPK, and PK/PD models for small molecule programs.
• Perform in silico simulations and create data visualizations for diverse audiences.
• Survey literature to abstract mechanisms and identify data for model incorporation.
• Propose experiments to test model assumptions and support preclinical translation.

📋 Requirements

• PhD in a quantitative discipline (systems pharmacology, computational biology, etc.).
• 0-2 years of industry experience in modeling.
• Proficiency in ODE-based modeling and parameter inference.
• Hands-on experience with MATLAB, Python, Julia, or R.

✨ Nice to Have

• Experience with diverse dynamical system methods (PDE, agent-based, etc.).
• Integration of large datasets into QSP models.
• Experience with modeling software (SimBiology, NONMEM, etc.).

🎁 Benefits & Perks

• 💰 Competitive cash compensation including base salary.
• 📈 Robust equity awards.
• 🏥 Strong benefits package.
• 📚 Learning and development opportunities.

📨 Hiring Process

Estimated timeline: 2-4 weeks · AI estimate

1. 1Phone Screen· 30 min
2. 2Technical Interview· 60 min
3. 3On-site Interview· half day