about 4 hours ago

Scientist II, Single Cell Automation (Contract)

Pleasanton, California, United States

$67-$80 / year

contractmidbiotechnology

Tech Stack

Description

In this contract role, you will support the development and adaptation of 10x single cell assays to automated workflows, troubleshoot complex systems, and collaborate with multidisciplinary teams. You'll execute single-cell assays, prepare NGS libraries, and optimize protocols to improve performance and robustness.

Requirements

  • B.S./M.S. or Ph.D. in chemistry, molecular biology, biochemistry, cell biology, or related field
  • B.S./M.S. with 7+ years or Ph.D. with 3+ years of relevant biotechnology or pharmaceutical industry experience preferred
  • Direct, demonstrable experience with advanced molecular technologies, particularly NGS workflows
  • Exceptional proficiency in molecular biology techniques: nucleic acid extraction, PCR/qPCR, NGS library preparation
  • Proven track record of using, optimizing, and troubleshooting molecular biology protocols
  • Experience with experimental design and statistical data analysis
  • Ability to perform complex multi-step experiments with detailed attention to planning, organization, and record keeping
  • Experience working with challenging clinical sample types (e.g., FFPE tissue, primary tumor cells, low-input samples)
  • Strong collaboration and communication skills
  • Desire to work in a flexible and fast-paced startup environment
  • Resourcefulness in sourcing alternative 3rd party consumables and reagents (preferred)
  • Experience operating and/or programming liquid handling systems (preferred)
  • Experience with product development lifecycle (preferred)

Responsibilities

  • Support the development, testing, and verification of new or existing Single Cell workflows on automated platforms
  • Hands-on execution of complex single-cell assays such as 10x Flex Gene Expression (sample processing, library preparation, sequencing, data analysis)
  • Prepare high-quality NGS libraries using Chromium and various liquid handling systems (e.g., Hamilton, Tecan, Beckman, SPT Labtech, Agilent)
  • Systematically troubleshoot, optimize, and refine specific steps within manual and automated assay workflows
  • Partner with R&D, Support, and Marketing to drive development and adoption of automation solutions
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