Tech Stack

Description

As a computational chemist at Cogent Biosciences, you will apply structure-based and ligand-based drug design methods to support discovery programs from hit identification through lead optimization. You will collaborate with multidisciplinary teams, develop predictive models, and present insights to guide molecular design. Your work will directly influence the development of novel precision therapies targeting unmet medical needs.

Requirements

• Ph.D. in Computational Chemistry or related field with 10+ years relevant industrial experience.
• Expertise in structure-based design, docking, virtual screening, pharmacophore modeling, and lead optimization.
• Expertise in MOE modeling software.
• Strong hands-on experience with Spotfire and cheminformatics platforms.
• Proficiency in Linux/UNIX, shell scripting, and HPC frameworks (SLURM, LSF, PBS/Torque).

Responsibilities

• Apply structure-based and ligand-based drug design methods including docking, protein modeling, and computational techniques.
• Collaborate with project teams in iterative structure-based drug design cycles to generate hypotheses and guide SAR exploration.
• Present modeling insights to cross-functional project teams.
• Develop, refine, and maintain computational workflows on HPC Linux environments.
• Train and mentor colleagues on computational chemistry tools and workflows.