Tech Stack

Description

You will lead a team of scientists supporting drug-creation programs at the intersection of antibody engineering, structural biology, and AI-enabled biologics discovery. This role contributes directly to advancing internal and partnered programs while embodying values of innovation, collaboration, and determination.

Requirements

• PhD in life sciences with 8+ years of experience (including 5+ years in biopharma or biotech) or MS with equivalent experience
• Proficiency in protein structure–function analysis and computational modeling (e.g., Schrödinger, MOE, Rosetta)
• Hands-on experience designing and optimizing bispecific and multispecific antibodies
• Deep understanding of antibody structure-function relationships, sequence optimization, and expression/purification workflows
• Experience in binding and interaction analyses (e.g., BLI, SPR) and/or biophysical characterization techniques (e.g., analytical SEC, DSF, DLS)
• Familiarity with Fc engineering, half-life extension strategies, antibody developability, and immunogenicity assessment
• Demonstrated success progressing one or more biologics programs to lead candidate stage
• Experience managing teams of PhD-level scientists and research associates
• Track record of peer-reviewed publications and/or patent filings
• Excellent oral, written, and interpersonal communication skills

Responsibilities

• Lead a multidisciplinary team focused on antibody engineering, structural biology, and binding characterization to support multiple internal and external drug-creation programs
• Mentor scientists and research associates, supporting technical development, scientific excellence, and career growth
• Partner closely with the AI team to align experimental and computational strategies supporting Absci’s generative AI drug-creation platform
• Serve as the protein engineering lead on cross-functional project teams
• Regularly summarize and present data to internal and external stakeholders
• Maintain awareness of emerging technologies and the competitive landscape in biologics discovery
• Lead efforts to develop and optimize platforms for mAb and multispecific therapeutics
• Rationally design molecules, perform antigen/antibody structural analyses to recommend residue-level changes
• Design and implement binding and biophysical assays to assess the mutation impacts on protein structure and function
• Coordinate closely with Absci teams to ensure high-quality protein expression, purification, and biophysical characterization
• Partner with Translational biology teams to provide mechanistic insight into target biology and antibody–target interactions