Tech Stack

Description

You will design and execute in vitro and in vivo metabolite identification studies, characterize metabolites to support drug development, and author regulatory DMPK sections. Join a team dedicated to developing novel targeted therapies for RAS-addicted cancers.

Requirements

• PhD in Pharmaceutical Sciences, Chemistry, Biochemistry, or related field with 3+ years of experience after graduation
• Hands-on experience in metabolite profiling using high resolution mass spectrometry
• Solid understanding of drug metabolism, pharmacokinetics, and ADME principles
• Experience with PK software (e.g. WinNonlin)
• Excellent communication, problem-solving, and independent experiment design skills

Responsibilities

• Design and execute in vitro and in vivo metabolite identification studies using liver microsomes, hepatocytes, recombinant enzymes, and biological samples
• Perform metabolite profiling and structural elucidation to support candidate selection, MIST analysis, and regulatory strategy
• Design and perform mechanistic studies to understand metabolic pathways and enzyme kinetics
• Author and review DMPK sections of regulatory submissions and respond to agency questions
• Build collaborative partnerships across functional areas