18h ago
Associate Scientist II
San Carlos, CA
$106.1k-$116.5k / year
contractmidbiotech
๐ผ About This Role
You'll contribute to the development of a robust process for generating the company's proprietary pneumococcal conjugate vaccine. Your focus will be on synthesis, purification, and analytical characterization of chemically modified polysaccharides and polysaccharide-protein conjugates. This contract role offers hands-on experience in conjugation development within a clinical-stage biotech.
๐ฏ What You'll Do
- Perform and optimize multi-step syntheses of protein-polysaccharide conjugates
- Purify polysaccharides and conjugates using dialysis, SEC, and TFF
- Analyze conjugates with colorimetric assays, HPLC, SEC-MALS, SDS-PAGE
- Maintain experimental records and contribute to troubleshooting
๐ Requirements
- BS degree in Chemistry, Biochemistry, or related field with 2+ years industry experience (or MS with 1+ year)
- Experience with protein purification methods such as dialysis, diafiltration, and SEC
- Working knowledge of analytical methods including colorimetric assays, HPLC, SEC, and SDS-PAGE
โจ Nice to Have
- Experience with TFF (tangential flow filtration)
- Hands-on experience with protein conjugation reactions or chemical polysaccharide modification
๐จ Hiring Process
Estimated timeline: 2-3 weeks ยท AI estimate
- 1Recruiter screenยท 30 min
- 2Technical interviewยท 60 min
- 3Hiring manager interviewยท 45 min
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