Tech Stack

Description

You will join the Translational Research team to develop physiologically-based PK and quantitative systems pharmacology models, design in vivo and ex vivo studies, and collaborate across functions to advance targeted therapies for RAS-addicted cancers.

Requirements

• Ph.D. in pharmacology, cancer biology, or quantitative discipline relevant to drug development.
• 2+ years of postdoc or industry experience in cancer drug discovery and development.
• Demonstrated experience in in vivo experiments with oncology disease models.
• Solid PK/PD knowledge and prior experience with PK/PD data collection and analysis.
• Strong theoretical understanding of PK/PD mathematical modeling concepts and limitations.

Responsibilities

• Develop and refine PBPK, QSP, and PK/PD models to support discovery and development projects.
• Apply innovative modeling approaches to understand tumor resistance to RAS(ON) inhibitors.
• Design and oversee in vivo and ex vivo studies (internally and via CROs).
• Develop and maintain high-quality protocols and documentation.
• Present results at internal forums and scientific conferences.