2h ago

Senior Scientist, Medicinal Chemistry

San Francisco, California
full-timeseniorbiotechnology

Tech Stack

Description

You will design and synthesize novel small molecules for hit-to-lead and lead optimization, collaborate with multidisciplinary teams, and provide scientific oversight of external resources to advance drug discovery projects from inception to clinic.

Requirements

  • Ph.D. in Organic or Medicinal Chemistry
  • Minimum 5 years as a medicinal chemist in pharma/biotech
  • Strong knowledge of state-of-the-art synthetic organic chemistry methodology
  • Working knowledge of structure-based drug design
  • Proficiency in computational modeling software (e.g., Maestro, MOE)

Responsibilities

  • Design and synthesize novel small molecules for hit-to-lead and lead optimization
  • Support and guide external chemistry resources with synthetic strategies and creative solutions
  • Advance small molecule hits and lead compounds into clinical candidates using structure-based drug design
  • Communicate scientific results and progress to stakeholders
  • Mentor internal talent and foster a culture of collegiality and scientific rigor
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