Tech Stack

Description

You will lead a multidisciplinary team driving in vitro and ex vivo functional characterization of next-generation biologics to advance Absci's discovery and preclinical pipeline. As the primary subject matter expert in pharmacology and mechanistic biology, you will ensure rigorous, reproducible data that informs program strategy from early discovery through IND-enabling studies. This critical scientific leadership role partners closely with Disease Biology, Protein Engineering, and High-Throughput Screening functions.

Requirements

• PhD in Pharmacology, Cell Biology, Biochemistry, Immunology, or a related discipline with 5-7+ years of industry experience, or an equivalent combination of advanced degree and experience
• Demonstrated track record of scientific leadership and team development
• Proven experience supporting or leading antibody drug development programs
• Deep expertise in pharmacology and mechanistic biology of biologics, including antibodies, bispecifics, and other engineered protein therapeutics
• Strong background in cell biology, including primary cell systems, cytokine biology, receptor–ligand interactions, signaling pathways, and effector function mechanisms
• Extensive experience developing, executing, and troubleshooting in vitro/ex vivo functional assays
• Demonstrated experience advancing biologic drug candidates through key stages of drug development, including target validation, lead optimization, and IND-enabling studies, with direct contribution to at least one successful IND submission
• Excellent communication skills with the ability to translate complex biological data into program-relevant insights
• Highly collaborative, strategic, proactive, and adaptable to evolving priorities
• Ability to thrive in a dynamic biotech environment and influence across functions

Responsibilities

• Lead, mentor, and develop a high-performing team focused on in vitro and ex vivo assay development, mechanistic biology, and functional pharmacology
• Oversee the design, development, optimization, and execution of cell-based functional assays that evaluate potency, mechanistic activity, selectivity, and biological relevance of therapeutic candidates
• Represent the Pharmacology Bioassays group on cross-functional project teams, translating complex data into actionable recommendations
• Build and maintain state-of-the-art workflows and technologies relevant for cell-based and ex vivo assay systems
• Manage team resources, timelines, and workload across multiple programs in a dynamic, fast-paced environment